Genome-wide noninvasive prenatal screening for carriers of balanced reciprocal translocations.

Flowers NJ, Burgess T, Giouzeppos O, et al. Genet Med. 2020;22(12):1944-1955. doi:10.1038/s41436-020-0930-2. Open Access: Learn more

Tags: Clinical Experience / Clinical Utility, 2020, Australia, CNVs

  • This pilot series comprises a retrospective analysis of GW-NIPS and clinical outcome data from 42 singleton pregnancies where one parent carried a balanced reciprocal translocation. GW-NIPS was performed between August 2015 and March 2018. Inclusion criteria required at least one translocation segment to be ≥15 Mb in size.
  • “Forty samples (95%) returned an informative result; 7 pregnancies (17.5%) were high risk for an unbalanced translocation and confirmed after diagnostic testing. The remaining 33 informative samples were low risk and confirmed after diagnostic testing or normal newborn physical exam. Test sensitivity of 100% (95% confidence interval [CI]: 64.6-100%) and specificity of 100% (95% CI: 89.6-100%) were observed for this pilot series.”
  • “We demonstrate that GW-NIPS is a potential option for a majority of reciprocal translocation carriers. Further confirmation of this methodology could lead to adoption of this noninvasive alternative.”