Perinatal outcomes of prenatal cases testing positive for trisomy 9 by noninvasive prenatal testing.

Li H, Lu L, Yao Y, et al. Taiwan J Obstet Gynecol. 2022;61(6):965-970. doi:10.1016/j.tjog.2022.07.006. Open Access: Learn more

Tags: Case Report / Case Series, 2022, Taiwan, RAAs

  • “Among the 16 cases [with NIPT results showing increased risk of trisomy 9], 2 cases of trisomy 9, 3 cases of trisomy 9 mosaicism, 2 cases reporting of regions of homozygosity and 9 cases of false positive were diagnosed. Among the true positive cases, 4 cases showed abnormal ultrasonic finding: 3 cases terminated pregnancy and 1 case was lost to follow-up. Another 1 case was in utero fetal demise in the second trimester without structural abnormality, and 2 cases were normal live birth without developmental abnormalities. In the 9 cases with normal karyotyping, 1 case had termination of pregnancy and 1 case with mental retardation and poor cognitive ability, other 7 had good pregnancy outcomes.”